Intellia Therapeutics Announces WT1 as Its First Cell Therapy Target, Following Presentation of Early Data at the American Society of Gene and Cell Therapy 21st Annual Meeting
“As Intellia expands its wholly owned T cell therapy ex vivo efforts, we are pleased to present our first set of data in this cell therapy area,” said Intellia President and Chief Executive Officer
Intellia and OSR are collaborating to develop best-in-class CRISPR-edited T cells directed to WT1, a tumor-associated antigen expressed across a wide range of different tumor types and a known driver of leukocyte blasts in hematological cancers. At this year’s ASGCT Annual Meeting, OSR researchers, led by
OSR researchers and Intellia presented the poster, entitled “Hunting WT1-Specific T Cell Receptors for TCR Gene Editing for Acute Myeloid Leukemia.” The abstract is available on the ASGCT website here.
“Our collaboration with Intellia represents our shared belief that the characteristics of T cell receptors as a targeting moiety may be an excellent approach to broadening the field of oncology cell therapy, opening the door to many more potential antigen targets in liquid and solid tumors,” added Bonini, full professor at Università Vita-Salute San Raffaele; deputy director,
This ex vivo research effort is part of an integrated strategy to develop CRISPR-edited T cell therapies to address hard-to-treat cancers and overcome certain limitations of current-generation cell therapies, including widely reported immune cell suppression in tumor microenvironments.
About Ospedale San Raffaele
Ospedale San Raffaele is a university and research hospital established in 1971 to provide international-level specialised care for the most complex and difficult health conditions. Since 2012, it has been part of Gruppo ospedaliero San Donato, the leading hospital group in
This press release contains "forward-looking statements" of Intellia within the meaning of the Private Securities Litigation Reform Act of 1995. These forward-looking statements include, but are not limited to, express or implied statements regarding our ability to advance and expand the CRISPR/Cas9 technology to develop into human therapeutic products, as well as our CRISPR/Cas9 intellectual property portfolio; our ability to achieve stable or effective genome editing; the potential development of ex vivo cell therapies of all types, including immuno-oncology and autoimmunity therapies, and those targeting WT1 in particular, using CRISPR/Cas9 technology; our intent to present additional data for WT1, other ex vivo programs (including programs developing cell therapies for other immuno-oncology and autoimmune/inflammation indications), in vivo therapies (including those focused on the liver and other organs), and additional insertion/repair data during 2018; and the impact of our collaborations on our development programs. Any forward-looking statements in this press release are based on management’s current expectations and beliefs of future events and are subject to a number of risks and uncertainties that could cause actual results to differ materially and adversely from those set forth in or implied by such forward-looking statements. These risks and uncertainties include, but are not limited to: risks related to Intellia’s ability to protect and maintain our intellectual property position; risks related to the ability of our licensors to protect and maintain their intellectual property position; uncertainties related to the initiation and conduct of studies and other development requirements for our product candidates; the risk that any one or more of Intellia’s product candidates will not be successfully developed and commercialized; the risk that the results of preclinical studies will be predictive of future results in connection with future studies; and the risk that Intellia’s collaborations with IRCCS Ospedale San Raffaele, or Intellia’s other ex vivo or in vivo collaborations will not continue or will not be successful. For a discussion of these and other risks and uncertainties, and other important factors, any of which could cause Intellia’s actual results to differ from those contained in the forward-looking statements, see the section entitled “Risk Factors” in Intellia’s most recent annual report on Form 10-K and quarterly reports on Form 10-Q filed with the
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Source: Intellia Therapeutics, Inc.